EWCBR/EBBS 2014 Final Program

Monday, March 17th
EBBS symposium: Why do we sleep? New insights on the principles of information processing and inter-regional communication in the brain during sleep.
Chair: Oxana Eschenko (Germany)
Monday, March 17th, 8:30 – 10:30
Spatio-temporal complexity of brain activity during sleep: functional significance and implications for sleep regulation
Vladyslav Vyazovskiy (GBR)
Francesco P. Battaglia (The Netherlands)
The functional and effective connectivity of memory-related networks: insights from the neural event triggered BOLD fMRI
Nikos K. Logothetis (GER)
Ripple-triggered stimulation of Locus Coeruleus during post-learning sleep impairs memory consolidation
Oxana Eschenko (GER)
Role of TRP channels in pain and inflammation
Chair: Felix Viana (Instituto de Neurociencias UMH-CSIC, Alicante, Spain)
Monday, March 17th, 8:30 – 10:30
TRP channels and pain
David Anderson (GBR)
On the interaction of TRPV1 and TRPA1
Michael Fischer (GER)
NO-TRPA1-CGRP signalling in the trigeminal system and its role in meningeal nociception
Karl Messlinger (GER)
TRPV1 modulation in the course of inflammation
Jan Siemens (GER)
Role of TRPA1 channels in inflammatory pain
Felix Viana (ESP)
ISN Symposium on RNA metabolism impairments in neuronal malfunctioning.
Chair: Hermona Soreq (The Hebrew University of Jerusalem, Israel) and Vania Prado (Western University, CAN)
supported by the International Society of Neuroscience


Monday, March 17th,16:30 – 19:30

Brain region-specific gene expression predicts the chronological age in human subjects
Jernej Ule (UK), jule@mrc-lmb.cam.ac.uk
MicroRNAs and the cellular role of the Microprocessor
Javier Caceres (SCO)
 Role of SR and hnRNP A/B protein families in cell proliferation and differentiation.
Adrian Krainer (USA)
Cholinergic regulation of hnRNP and alternative splicing: Implication in Alzheimer’s disease.
Vania Prado (CAN)
Multi-leveled RNA metabolism errors in Alzheimer’s disease
Hermona Soreq (IL)
Linking inflammation and behavior: Models and mechanisms
Chair: Mats Lekander (Karolinska Institute, Sweden)
Monday, March 17th,16:30 – 19:30
Perception of sickness and fatigue: causes and consequences
John Axelsson (SWE)
Linking inflammation and behavior: the processing of immune derived signals in the brain
Harald Engler (GER)
The contribution of the peripheral immune system in the regulation of inflammatory pain and chemotherapy-induced peripheral neuropathy
Cobi Heijnen (NLD)
Inflammation diminishes sensitivity to reward but enhances sensitivity to punishment.
Neil Harrison (GBR)
Experimental models to disentangle immune-to-brain communication
Manfred Schedlowski (GER)
TNFα in the transition from acute to chronic neuropathic pain
David Fink (USA)
Tuesday, March 18th
EBBS symposium: Behaviour meets psychology meets biology meets engineering.
Chairs: Simone Macrì (Istituto Superiore di Sanità,Italy) and Nicole Abaid (Virginia Tech, USA)
Tuesday, March 18th, 8:30 – 10:30
Pitfalls in behavioural neuroscience
Simone Macrì (ITA)
Fish ‘n’ CHIPS: use of robots to modulate zebrafish behavior
Giovanni Polverino and Jeffrey Laut (USA)
Fish ‘n’ CHIPS round trip: use of live stimuli to modulate robots’ behaviour and vice versa
Nicole Abaid (USA)
Human-robot interaction: assistive robot technologies in neurorehabilitation
Marco Germanotta (ITA)
G protein-coupled receptors and plasticity in health and disease
Chairs: Andy Irving (GBR) and Andy Randall (GBR)
Tuesday, March 18th, 8:30 – 10:30
Dopamine regulates synaptic function in prefontal cortex by altering NMDAR activity
Zafar Bashir (GBR)
Synaptic kainate signalling and modulation of intrinsic excitability in the hippocampus
Jack Mellor (GBR)
A role for GPR30 and estrogen in regulating hippocampal function?
Andy Irving (GBR)
The neurobiology of MeCP2 - Reversing phenotypes in mouse models of Rett Syndrome
Stuart Cobb (GBR)
Proteinase -activated receptor 2 (PAR2): Do peripheral inflammatory roles translate to the CNS?
Trevor Bushell (GBR)
Chronic pain and inflammation I
Chairs: Steve McMahon (Kings College London, UK) and Jordi Serra (Neuroscience Technologies, Spain)
Tuesday, March 18th, 16:30 – 19:30
The role of FAM-173b as a novel player in inflammatory pain
Niels Eijkelkamp (NLD)
The role of inflammation and stress in human visceral pain
Sigrid Elsenbruch (GER)
Pharmacological modulation of spontaneous activity in C-nociceptors
Jordi Serra (ESP)
Inflammatory pain mediators
Steve McMahon (GBR)
Pain regulation and expectation processing in health and disease
Predrag Petrovic (SWE)
The role of CaV3.2 T-type channels in painful diabetic neuropathy
Slobodvan Todorovic (USA)
The lateral habenula and its influence on depression-related networks
Chair: Rainer Spanagel (Zentralinstitut für Seelische Gesundheit, Mannheim, Germany)
Tuesday, March 18th, 16:30 – 19:30
Functional connectivity of the habenula in humans
Martin Walter (GER)
Functional imaging in an animal model of treatment resistant depression
Alexander Sartorius and Barbara Vollmayr (GER)
Changes of the monoaminergic tone after deep brain stimulation
Lucas Lecourtier (FRA)
Dopaminergic and serotonergic coupling by the lateral habenula
Gadi Goelman (ISR)
Regional cerebral blood volume and voxel-based morphometry interaction of the habenular neurocircuitry.
Wolfgang Weber-Fahr (GER)
21:00 IBRO-PERC sponsored Plenary Lecture
Title: Hippocampal place cell firing and goal-directed spatial navigation
Bruno Poucet (FRA)
Wednesday, March 19th
Connexins and Pannexins in Neuroglial Interactions
Chair: Christian Naus (University of British Columbia, CAN)
Wednesday, March 19th, 8:30 – 10:30
Connexins and Pannexins in Stroke
Christian Naus (CAN)
Activity-dependence of Astroglial Connexin Channels in the Olfactory Bulb
Christian Giaume (FRA)
Role of Hemichannels in Mastocytes During the Development of Alzheimer Disease
Juan Saez (CHI)
The Role of Connexins in the Blood Brain Barrier
Luc Leybaer (BEL)
Breakthrough in experimental psychopathology: coupling behavioural models with real-time monitoring and manipulation of neuronal function
Chair: Véronique Deroche-Gamonet (INSERM, Bordeaux, France)
Wednesday, March 19th, 8:30 – 10:30
Neuronal ensembles in addiction
Bruce Hope (USA)
Transition to cocaine addiction: sequential hierarchical loss of synaptic plasticity from the nucleus accumbens to the prelimbic cortex?
Véronique Deroche-Gamonet (FRA)
Prefrontal parvalbumin interneurons shape neuronal activity to drive fear behavior
Cyril Herry (FRA)
Disruption of reconsolidation erases a fear memory trace in the human amygdala
Thomas Agren (SWE)
Vulnerability to Addictions: Dopamine Studies in Humans
Marco Leyton (CAN)
Chronic pain and inflammation II
Chair: Peter Reeh (University Erlangen, GER)
Wednesday, March 19th, 16:30 – 19:30
The formalin test is a case of 'anaesthesia dolorosa
Peter Reeh (GER)
Analgesic effects and mechanisms of action of non-invasive brain stimulation. A new treatment option for chronic pain?
Didier Bouhassira (FRA)
New insights into endocannabinoid-based therapeutic drugs for chronic pain
Katarzyna Starowicz (POL)
Targeting cannabinoid receptors in activated microglia to manage neuroinflammation
Natalia Malek (POL)
Targeting the GRK2-EPAC interface to prevent or treat chronic pain.
Annemieke Kavelaars (NDL)
The role of cytokines and TRPV1 receptors in spinal cord nociceptive modulation
Jiri Palecek (CZR)
EBBS-sponsored Young Investigator Symposium I
Chair: Mathias Schmidt (GER)
Wednesday, March 19th, 16:30 – 19:30
Antidepressant treatment outcome depends on the quality of the living environment: a preclinical investigation in mice.
Silvia Poggini (ITA)
The Causes and Consequences of the Regulation of Protein Synthesis at the Elongation Phase in Cortical Neurons
Justin W. Kenney (GBR)
The cell adhesion molecule neuroligin-2 as a novel modulator of social behavior and vulnerability to early life stress
Christine Kohl (GER)
Elucidating novel candidate genes and pathways determining variability in antidepressant response
Christiana Labermaier (GER)
Activity-dependent changes in synaptic strength and molecules related with synaptic transmission, taking place in the reward circuit during associative learning
María Ángeles Gómez Climent (ESP)
Regulation of post-synaptic function by the dementia-related ESCRT-III subunit CHMP2B
José Martínez-Hernández (ESP)
Thursday, March 20th
EBBS Symposium: Contribution of dorsal striatum circuits to the control of goal-directed behavior, learning and drug-induced sensitization
Chairs: Marianne Amalric and Francesca Sargolini (Aix-Marseille University, France)
Thursday, March 20th, 8:30 – 10:30
Striatal cholinergic interneurons control motor function and basal ganglia outflow in the parkinsonian condition
Corinne Beurrier (FRA)
Dissociating model-based and model-free reinforcement learning mechanisms using a multi-step decision task in mice
Thomas Akam (POR)
Goal-directed action in rats: cortico-striatal function and neurochemical modulation
Wolfgang Hauber (GER)
Changes in reward probability alter the firing pattern of dorsal striatal neurons
Francesca Sargolini (FRA)
EBBS-sponsored Young Investigator Symposium II
Chair: Mathias Schmidt (GER)
Thursday, March 20th, 8:30 – 10:30
Behavioural and molecular characterization of SLC6A15 function in an animal model
Sara Santarelli (GER)
The role of endocannabinoid signaling in mediating effects of several stress
systems in memory consolidation
Piray Atsak (NLD)
NPFF-dependent dynamic balance of oxytocin and vasopressin: behavioral effects
Olga Lopatina (FIN)
The role of the X-linked EFHC2 gene in social cognition in males
Carla M Startin (UK)
Altered neuroplasticity in chronic tension-type headache
Ann-Maree Vallence (AUS)
Different influence of amygdala nuclei on behaviors in rat models of autism
Kacper Ptaszek (POL)
Functional consequences of tauopathy in the mammalian brain
Chairs: John Isaac (Eli Lilly, UK), Zaf Bashir (University of Exeter, UK)
Thursday, March 20th, 16:30 – 19:30
Propagation of tau pathology in Alzheimer's disease
Amy Pooler (GBR)
Progressive anatomical, biochemical and electrophysiological changes in tauopathy
John Isaac (GBR)
Tauopathy-induced alterations to intrinsic neuronal properties and GPCR-mediated synaptic responses and plasticity
Andy Randall (GBR)
Tauopathy-induced neurophysiological change studied in awake behaving mice
Jon Witton (GBR)
Longitudinal in vivo multiphoton imaging of the structural consequences of tauopathy in the mouse cortex
Mike Ashby (GBR)
Epilepsy and its comorbidities
Chairs: Claude Wasterlain (USA) & Rene Pumain (France)
Thursday, March 20th, 16:30 – 19:30
Clinical Epilepsy for the basic scientist
Sami Harik (USA)
BFNIS-associated SCN2A mutation causes cellular and network hyperexcitability in neonatal mouse brain
Dirk Isbrandt (GER)
Excitotoxicity: The Mechanism Responsible for All Acute Neuronal Injury, Including Status Epilepticus
Denny Fujikawa
Rene Pumain (FRA)
The universal nature of seizures
Christophe Bernard (GER)
Emergence of depression like symptoms after repeated mild concussions
Andre Obenaus (USA)
Simultaneous EEG and fMRI recording in Epilepsy - Methodological considerations
Olaf B. Paulson (DK)
Hypothermia for the treatment of refractory status epilepticus
Claude Wasterlain (USA)
Friday, March 21st
How does the neocortex work? From neural circuit organisation to emergent computations.
Chair: Andreas Tolias (Rice University, Houston, USA)
Friday, March 21st, 8:30 – 10:30
Organisation of the neocortical microcircuit
Andreas Tolias (USA)
Carl Petersen (CHE)
State dependence of noise correlations in primary visual cortex
Alexander Ecker (GER)
Plasticity in the neocortex
Stelios Smirnakis (USA)
EBBS symposium: Developmental Origins of Healthy and Unhealthy Ageing: an integrated approach to understanding early programming of brain function
Chair: Francesca Cirulli (Istituto Superiore di Sanità, Italy)
Friday, March 21st, 8:30 – 10:30
Fetal programming of chronic diseases: revisiting the Barker hypothesis after 20 years of research
Katri Räikkönen (FIN)


Animal models of metabolic dysfunction
Patricia Iozzo (ITA)


Long-term effects of prenatal exposure to high fat diet in an animal model of healthy aging
Veronica Bellisario (ITA)
Individual vulnerability to high fat diet exposure: role of FKBP5 in mediating effects of metabolic dysfunction on brain and behavior
Georgia Balsevich (GER)
EBBS symposium: Diverse functions of the brain’s reward system.
Chair: Philippe Tobler (University of Zurich, Switzerland)
Friday, March 21st, 16:30 – 19:30
Risky business I: Coding of risky rewards by neurons in the frontal cortex
Martin O’Neill (GBR)
Risky business II: Neural coding of risky rewards assessed by fMRI
Philippe Tobler (CHE)
Knowing me, knowing you: Neuronal correlates of social reward values
Tobias Kalenscher (GER)
Modulation of risk-seeking choices by value and effort
Igor Kagan (GER)
Space and Time: Covert orienting of attention to space and time in goal-directed behaviour and the effects of selective antagonism of dopamine receptors
Verity J Brown (GBR)
Action time: A mechanistic account of value-based action selection in intertemporal choice
Sam McClure (USA)